The extent of their injuries is not known, a source briefed on the incident told CNN.
The plane is a Bombardier Challenger 650 business jet.
The airport told CNN in a statement emergency crews responded to an incident around 7:45 p.m. ET.
“First responders are still on the scene and are expected to be actively working the site for several more hours before any additional information is available,” the City of Bangor and Bangor International Airport said in a statement Sunday, adding that an emergency operation center has been established.
The crash comes amid a massive snowstorm making its way through the Northeast. Temperatures are well below freezing in Maine, with light snow causing very low visibility.
The plane is registered to a limited liability corporation in Houston, according to federal records.
Minutes before the crash, controllers and pilots at Bangor Airport can be heard talking about low visibility and deicing, though it is not immediately clear who is talking to whom, according to audio obtained from LiveATC.net.
A controller clears the pilot for takeoff on Bangor’s Runway 33.
Nearly two minutes later, a controller loudly radios: “All traffic is stopped on the field! All traffic is stopped on the field!”