Melbourne factory fire under control but expected to burn for days

Emergency services were called to Swann Drive in Derrimut about ?11.20am yesterday after a chemical explosion sparked the blaze.

The fire was deemed under control at 3.32pm after 180 firefighters and more than 50 trucks responded to the "seventh alarm" fire.

Police confirmed no injuries were ?reported as everyone in the warehouse and neighbouring properties were safely evacuated.

Residents in Derrimut and Laverton North have been warned to keep their windows closed due to toxic smoke, though this advice could change as wind keeps up this morning.

People have also been warned to avoid contact with water from Cherry Creek, Anderson's Swamp, and Kayes Drain, which have been contaminated by runoff.

The Environment Protection Authority said "no ash impacts" had been observed but urged people in the affected area to wipe down surfaces if they spotted ash, and to wash fruits and vegetables before eating them.?

Further updates are expected later this morning.?

9News understands it was the second fire at the same factory in less than a year after it went up in flames in October, resulting in the death of a 44-year-old man.

WorkSafe is responding and will investigate the company.