Iranian media say Khamenei’s daughter, son-in-law and his grand son were also killed. AlJazeera reported.

US President Donald Trump, who announced “major combat operations” in Iran after Israel launched missile attacks against the country, says the bombing will continue “uninterrupted throughout the week or, as long as necessary” to achieve his objectives.

Iranian state media say a strike on a school in southern Iran has killed at least 108 people, and that at least 201 people have been killed across 24 provinces.

Iran’s retaliatory attacks have targeted Israel and US assets in multiple Middle East countries, including Qatar, the UAE, Kuwait, Bahrain, Jordan, Saudi Arabia and Iraq.

Several countries across the region have shut their airspace amid the exchange of attacks.