The US Central Command (Centcom) said fighter jets, attack helicopters and artillery "struck more than 70 targets at multiple locations across central Syria". Aircraft from Jordan were also involved. BBC reported.
It said the operation "employed more than 100 precision munitions" targeting known IS infrastructure and weapons sites.
President Donald Trump said "we are striking very strongly" against IS strongholds, following the 13 December IS ambush in the city of Palmyra in which two US soldiers and a US civilian interpreter were killed.