This afternoon, they will walk to the Sistine Chapel to cast their votes beneath the famous Renaissance frescoes.BBC reported.
Once cardinals enter the chapel, around 17:30 local time (16:30 BST), they will have no communication with the outside world until a new Pope is elected
This marks the beginning of the conclave - which comes from the Latin for "cum clave", or "locked with key"
After the first vote later today, smoke will emerge from the Sistine Chapel chimney – black smoke means more voting will take place tomorrow, white means we have a new pope