The explosion occurred at Khadija Tul Kubra mosque, in southeastern Islamabad’s Tarlai Kalan area, during Friday prayers. Aljazeera reported.
Rescue teams have reached the site of the explosion.
At least 15 of those injured were taken to hospitals with some of them in critical condition, rescue official Mohamed Amir said, according to dpa news agency.
Islamabad police spokesperson Taqi Jawad said the cause of the blast has yet to be determined, local news outlet Dawn reported.
In November last year, a suicide bomber blew himself up at the entrance of the Islamabad District Judicial Complex, killing at least 12 people and wounding dozens.