The blast is the second in a place of worship since Islamist authorities took charge of the country a year ago, after a suicide bombing in a Damascus church killed 25 people in June. BBC reported.
State news agency SANA reported "an explosion inside the Imam Ali Bin Abi Talib Mosque in the Wadi al-Dahab neighbourhood" in Homs city.
Quoting a health ministry official, SANA gave a preliminary toll of at least eight dead and 18 wounded.
Syria's interior ministry said in a statement that "a terrorist explosion" targeted the mosque "during Friday prayers".
Homs was the scene of heavy sectarian violence during Syria's civil war.
The ministry imposed a security cordon around the mosque, saying that authorities "have begun investigating and collecting evidence to pursue the perpetrators of this criminal act".
