Take-offs and landings were suspended between 8:08 pm (1908 GMT) and 9:58 pm and a "whole series of flights" were diverted to other German cities during the closure, the spokesman said. NDTV reported.
Berlin's ban on night flights was also relaxed to mitigate the impact on fight operations, he added.
"We assume that the danger has been averted for the time being," the spokesman said.
German leaders have repeatedly raised the alarm about a growing drone threat after a series of sightings of unmanned aerial vehicles (UAVs) at airports as well as sensitive military sites this year.
Airports in Denmark, Norway and Poland have also recently suspended flights due to unidentified drones, while Romania and Estonia have pointed the finger at Russia, which has brushed off the allegations.