The US president wrote on social media that Maduro and his wife, First Lady Cilia Flores, had been flown out of the country. Their current whereabouts are unclear.
The Venezuelan defence minister, Vladimir Padrino, has said that the armed forces would defend the country's sovereignty.BBC reported.
The strikes inside Venezuela come after a US pressure campaign against the Maduro government, which the Trump administration accuses of flooding the US with drugs and gang members.
This coupled with the fact that Venezuela's Vice-President Delcy Rodríguez has said that she does not know where Maduro is or whether he is still alive indicates that Maduro has indeed been deposed from office.
However, the Venezuelan defence minister and Rodríguez are still in the country and have appeared on state television, indicating that key members of Maduro's government appear to remain in power.
There is little detail so far about how the US operation was carried out.
Video footage from inside Venezuela shows large explosions and residents of the capital, Caracas, reported hearing aircraft and blasts.
Smoke could also been seen rising from the different parts of the capital and helicopters could be seen flying in convoy
Several military installations were reportedly hit.
US officials told the BBC's US partner, CBS News, that the strikes had been ordered by the Trump administration.
They also told CBS News that Nicolás Maduro had been captured by the US military's top counter-terrorism unit, the Delta force. But we have no further details about the reported capture so far.
The Venezuelan government confirmed that Caracas had been attacked and said that there had also been strikes in the states of Miranda, La Guaira and Aragua.
Nicolás Maduro rose to prominence under the leadership of left-wing President Hugo Chávez and his United Socialist Party of Venezuela (PSUV).
Maduro, a former bus driver and union leader, succeeded Chávez and has been president since 2013.
During the 26 years that Chávez and Maduro have been in power, their party has gained control of key institutions including the National Assembly, much of the judiciary, and the electoral council.
In 2024, Maduro was declared winner of the presidential election, even though voting tallies collected by the opposition suggested that its candidate, Edmundo González, had won by a landslide.
González had replaced the main opposition leader, María Corina Machado, on the ballot after she was barred from running for office.
She was awarded the Nobel Peace Prize in October for "her struggle to achieve a just and peaceful transition from dictatorship to democracy".
Machado defied a travel ban and made her way to Oslo in December to collect the award after months in hiding.
She said that she planned to return to Venezuela, a move which would put her at risk of arrest by the Venezuelan authorities, who have declared her a "fugitive".