At least two people were killed Friday after a small plane crashed onto a busy road and collided with a bus in Sao Paulo,southern Brazil, leaving charred aircraft parts strewn along the highway.

 The crash took place around 7:20 a.m. local time (5:20 a.m. ET) along Avenida Marquês in the coastal district of Barra Funda, CNN affiliate CNN Brasil reported.

Two aircraft passengers were burned to death, according to military police. Six other people were injured, including a motorcyclist and a woman on the bus who were both hit by flying debris.

Footage from the aftermath on Friday showed black clouds of smoke and bright orange flames unfurling over the highway.

The small twin-engine King Air plane – which was en route to Porto Alegre in the southern state of Rio Grande do Sul – took off from Campo de Marte Airport on Friday morning, but the control tower lost contact with the aircraft minutes before the crash.

According to the Associated Press, the plane smashed into the road less than 3 miles (5 kilometers) from where it took off.