In a surprise announcement on Thursday, the first lady called for congressional hearings for survivors of Epstein's sex trafficking. BBC reported.
She also denied online rumours that Epstein introduced her to Donald Trump, calling them "mean-spirited attempts to defame my reputation".
It is unclear what prompted the announcement.
There was no prior indication from her office that she would make a statement on Epstein, and the White House did not share the topic earlier when her remarks were put on its daily schedule.
She said she had not been a victim of Epstein, with whom she only briefly "crossed paths" in 2000.
I have never had any knowledge of Epstein abuse of his victims," she said. "I was never involved in any capacity. I was not a participant."
She also denied knowing Ghislaine Maxwell, the disgraced financier's jailed associate.
She referred to a 2002 email between her and Maxwell released in the Epstein files, calling it nothing more than "casual correspondence" and a "polite reply".
An email that appears to be the one she referenced is addressed to "G" - presumably for Ghislaine - and includes compliments about a story featuring "JE" with a photo of G that appeared in New York Magazine. She wrote that she "cannot wait" to go to Palm Beach.
"Give me a call when you are back in NY," the email says. "Have a great time! Love, Melania"
The New York Magazine article included quotes from now-President Donald Trump calling Epstein a "terrific guy" and saying "he's a lot of fun to be with".
